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White Papers

Deteriorating Retinal function has been shown to be involved in the etiology of Parkinson’s disease (PD). However, recent work suggests that PD may be caused or worsened by retinal deterioration. Research also shows that treating Parkinson’s via the eye not only causes symptomatic improvement, but may also be disease modifying. Animal studies have shown light to be more effective than dopamine or other medications, and preliminary human studies have shown similar responses. A pivotal, double-blind study is currently underway to verify these findings.

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Work in light therapy and Parkinson’s disease reveals that light may have a beneficial effect on both motor and non-motor symptoms. Bradykinesia, tremor, rigidity, sleep and depression have all shown significant improvement in placebo controlled and also long‐term open label studies. Several pilot studies along with unpublished data from a long‐term retrospective analysis have helped to identify an optimal, low intensity phototherapy device that enhances specific bandwidths while avoiding the potentially problematic wavelengths. The risk‐benefit ratio demonstrated by the pre‐clinical and clinical work that has been done is sufficient to warrant a longer term, double‐blind study with phototherapy.

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